4DryField PH Haemostasis With Adhesion Prevention UK

surgeon looking at 4 dry field starch based adhesion barrier bottle

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Proven efficacy as both
an adhesion barrier and haemostat with
68-100% adhesion reduction 1-8.

What is 4DryField® PH?

How does it work?

4DryField® PH is the first CE certified Class III medical device which innovatively combines haemostasis with adhesion prevention. It can be used in a wide range of surgeries, but has been particularly well studied in gynaecology, minimising adhesions following abdomino-pelvic surgery.

4DryField PH is made of sterile hydrophilic microparticles, manufactured from highly purified potato starch. It contains no animal components, is biocompatible, absorbable, pyrogen-free, and hypoallergenic. There are no known side effects.

In contrast to other starch-based haemostats which are typically reabsorbed after 2 days, 4DryField PH is reabsorbed after 7 days, meaning it remains in the body as a barrier until the mesothelial tissue has healed. This enables 4DryField PH to effectively prevent adhesion formation in addition to haemostasis.

As a powder haemostat

4DryField PH is applied directly to area of bleeding and absorbs water from the blood. This increases the relative concentration of coagulation factors, resulting in safe and immediate haemostasis. Even with a 50% dilution of the blood, the coagulum induced by 4DryField PH shows excellent stability 9.

As a gel adhesion barrier

When saline solution is applied, 4DryField PH transforms into a viscous gel due to its molecular properties. This acts as a mechanical barrier, separating adjacent tissues, minimising the formation of fibrinous connections and creating optimal conditions for healing without adhesion formation. The gel barrier is absorbed by the body over 7 days, prolonging time for healing.

Around >93% of patients will develop postoperative adhesions following transperitoneal surgery 10.

Adhesions can cause chronic or recurrent pain, infertility, intestinal obstruction, dyspareunia, and transit disorders 11. Using an adhesion barrier can help reduce readmissions and decrease hospital stay, thereby reducing costs and staff workload 12, 13, 14.

Key Benefits

Cost Effective

Extensively Researched with Proven Efficacy and Improved Outcomes

Excellent Safety Profile

Versatile

Easy to Use

Adhesion Reduction Performance 1

4DryField cost analysis - 4df has the lowest upfront cost of any available adhesion barrier

Literature and Resources

Scientist reading data on computer screen in lab

References

All studies referenced on this page are listed in the document linked here.

For more studies and resources, visit the resources page. Find this in main menu at the top of the page.

Brochure

Product Information

- Available in different sizes: 3g and 5g
- Also available, 4DFLapTM is a single use applicator for manual administration of 4DryField® PH in endoscopic and laparoscopic surgery.
- Storage: Room temperature, not exposed to extreme temperatures. Use promptly after opening the application. Used non-sterile product must be disposed of. 4DryField® PH has a shelf life of 5 years.

Haemostasis MOA Video

After 4DryField® PH powder is applied for hemostasis, the hydrophilic particles absorb the water from the blood. As a results, all of blood components partaking in hemostasis are contrated, leading to significantly accelerated clot formation and wound closure.
4DryField® PHs ability to accelerate hemostasis (even under conditions of coagulopathy) is examined and affirmed in Sieg et al. ARC Journal of Anesthesiology 2017, 2(4): 10-17

Literature Summary

FAQs

How can 4DryField PH be both a haemostat and an adhesion barrier?

How can 4DryField PH be applied?

Is 4DryField PH well tolerated?

Should 4DryField PH always be turned into a gel during a procedure?

How much saline should be applied to the powder?

Which procedures can 4DryField PH be used with?

Trial 4DryField PH for free in your hospital.

Your dedicated account manager will provide personalised support tailored to your hospital’s needs and protocols.

We will provide training for all relevant staff and assist with business cases and cost analyses.